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Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power

It tethers vesicles to the plasma membrane, facilitating sound encoding. tm,cc,jp

Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding. Upon binding, a "closed" conformation is adopted, where

Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power Sensing: The C2D domain is identified as critical,

The protein utilizes several C2 domains (C2A-C2F) to bind Ca 2+raised to the 2 plus power and lipids, as shown in the protein structure below. 2. C2 Domains: Function & Interactions

Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power