The series centers on the rise of a street gang known as the 3rd Street Saints . While the original series followed a linear progression from street-level warfare to global celebrity and eventually a battle against aliens, the most recent Saints Row (2022) rebooted the universe with a fresh start. The Story of the Saints Row Reboot (2022)

: The Saints must dismantle three major factions: Los Panteros : A gritty, vehicle-obsessed gang.

: Early struggles that lead the friends to turn to crime.

: High-tech private military forces trying to eradicate all other gangs while increasing their own corporate influence. Key Story Missions

The reboot takes place in , a fictional city in the American Southwest modeled after Las Vegas.

: After being cast out of their respective organizations, the four friends decide to "be their own boss" and form The Saints . They set up operations in a derelict church and work to take over nine city districts from rival gangs.