In the second part, "Wilson's Heart," the team discovers Amber is suffering from multisystem organ failure.
: The finale fundamentally alters the series' core relationship. Wilson is left alone, finding a final note from Amber, while House awakens from a coma to face the wreckage of his friendship.
The finale begins with House suffering from retrograde amnesia following a bus accident. Convinced he witnessed a life-threatening symptom in a fellow passenger before the crash, House undergoes increasingly dangerous procedures—including hypnosis and deep brain stimulation—to retrieve the lost memory.