[s11e1] Out Of The Darkness, Into The Fire Instant

Sam didn't answer immediately. He was staring at the road ahead, where the asphalt seemed to shimmer with heat that shouldn't be there. "We let it out, Dean. We actually let it out."

The sky above the Impala didn't just go dark; it bruised, a deep, oily purple that bled into the horizon like ink in water. Sam and Dean Winchester stood by the hood, the ringing in their ears finally fading, replaced by a silence so heavy it felt physical. They had just released the Darkness—an ancient, primordial force—and the world didn't end with a bang. It ended with a breath. [S11E1] Out of the Darkness, Into the Fire

Suddenly, a woman emerged from the ditch, her movements jerky and unnatural. Her skin was a map of dark lines, and when she looked at them, there was no humanity left—only a primal, screaming hunger. She lunged. Sam didn't answer immediately

They climbed back into the car, the rumble of the engine the only familiar thing left in a world that had suddenly turned alien. As they drove toward the nearest town, Superior, Nebraska, the signs of the "Darkness" began to manifest. It wasn't monsters in the shadows; it was a sickness. We actually let it out

"It’s a localized infection," Sam whispered, hopping out of the car to inspect a fallen road worker. "Whatever that smoke was, it changed them."

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If you want to explore more about this specific era of the show: The psychological bond between Sam’s secret struggle with the Rabid infection Castiel’s torture at the hands of the angels