Pcrmp4

: PCRMP4 is not required for the parasite's survival during the blood-stage of infection (the stage that causes symptoms in humans), but it is absolutely necessary for completing the complex life cycle through the mosquito. Research and Medical Context

: Note that PCRMP4 is distinct from pCRMP4 (phosphorylated Collapsin Response Mediator Protein 4), a human protein involved in axonal growth, spinal cord injury response, and certain cancers like pancreatic cancer. pcrmp4

: The protein contains specific motifs, including Cysteine Repeat Modular (CRM) domains and EGF-like domains, which are often involved in protein-protein or host-parasite interactions. : PCRMP4 is not required for the parasite's

PCRMP4 is essential for the transmission of malaria. Its primary known functions include: PCRMP4 is essential for the transmission of malaria

: Research involving Plasmodium berghei (a rodent malaria model) showed that deleting the pcrmp4 gene resulted in parasites that could form normal oocysts but could not progress further in the transmission cycle.

: Although PCRMP4-deficient parasites are severely impaired in the liver, experiments have shown that immunization with these live, genetically-attenuated sporozoites does not induce a strong protective immune response compared to other attenuated strains.

Plasmodium Cysteine Repeat Modular Proteins 3 and 4 are ... - NCBI