: Frank's fiancée and dental hygienist, Jean (Laura Dern), is also embroiled in the chaos as Frank's life is dismantled by Susan and her psychopathic brother, Duane (Scott Caan).

A self-absorbed actor shadowing the police (uncredited cameo)

: Susan seduces Frank and convinces him to prescribe her potent painkillers. Shortly after, Frank discovers that his entire drug inventory has been stolen from his practice.

: Frank becomes a murder suspect when a drug dealer—revealed to be Susan’s brother—is found dead. His attempts to cover up his minor indiscretions lead to a series of lies that draw him deeper into a world of illicit sex, drugs, and violence.