If you have downloaded the ISO, here is how you typically get it running:
This means the game file isn't locked to a specific part of the world (like NTSC for North America or PAL for Europe). You can run it on compatible hardware or emulators regardless of where you bought your console. NBA 2K16 [Region Free][ISO]
A legitimate NBA 2K16 ISO should be roughly 7GB to 15GB depending on the console version. If the file is only a few megabytes, it’s a virus. If you have downloaded the ISO, here is